MADRID, Spain -- Lionel Messi could be done for the season after he was ruled out for up to three weeks because of his nagging hamstring injury, meaning hes set to fall short of breaking his own Spanish league scoring record. Barcelona said Tuesday that the four-time FIFA player of the year has re-aggravated the right hamstring strain that has limited him for the last six weeks and only a quicker-than-expected return to fitness would see him play again for the Spanish team this season. Barcelona said Messi will be sidelined for two to three weeks, with the teams last -- and meaningless -- league game against Malaga scheduled for June 1. Barcelona has already clinched the league title with three games left, but Messi is four goals short of matching his own record of 50 goals that he set last year. But with 46 league goals, eight in the Champions League and four in the Copa del Rey, his grip on the European Golden Shoe award is likely to remain unchallenged. The other two matches which Messi is set to miss are against Valladolid and the Catalan derby against Espanyol. Messi first injured his hamstring on April 2 in the first leg of the Champions League quarterfinal against Paris Saint-Germain, and re-aggravated the injury in Sundays 2-1 win at Atletico Madrid. The win over Atletico was only the fifth league game this season in which Messi played but failed to score -- having netted in 21 consecutive previous appearances. Messi, who was making his first league start since the injury, left the pitch in the 68th minute after Barcelona had made all three substitutions and was trailing 1-0. The team rallied without him. 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CHERBOURG-EN-COTENTIN, France -- The Tour de France can rarely be won in the first week.It can be lost, though.Stage 2 on Sunday was a case in point.Four contenders for the overall title lost time over a wet and challenging route that resembled a course for a single-day classic, with two short climbs -- one of them very steep -- near the finish.If a key contender continues to lose time over easier stages in the first week, he will find it difficult to get back into contention once the mountains come later in the race.Vincenzo Nibali, the 2014 champion from Italy, and top French hope Thibaut Pinot each finished 11 seconds behind stage winner Peter Sagan as they struggled up the final climb.It was like a classics finale, on slippery roads, a bit complicated, Pinot said. There are still a couple of tricky stages to come. I need to be patient but all in all Im satisfied.Two-time Tour winner Alberto Contador fell to the ground for the second consecutive day and lost 48 seconds.I lost more time than I had hoped to lose, Contador said. I hit the handlebars and I was hurt on the other side from yesterday. I must stay calm, not lose morale. ... The Tour has really started on the wrong fting. Im not happy at all. Its cycling. I must seee if I can make up some time in the Pyrenees and the Alps.ddddddddddddRichie Porte, the co-captain of the BMC squad with American standout Tejay van Garderen, punctured a tire toward the end and didnt have any teammates to help him ride back into the peloton. Porte dropped 1 minute, 45 seconds -- likely ending his chances of overall victory.Porte, an Australian, was Chris Frmes top support rider at Team Sky during the Britons Tour wins in 2013 and 2015. He joined the BMC squad for this season with hopes of individual glory.Frme, the Kenyan-born British rider who is favored to defend his title, is placed well in fifth overall, 14 seconds behind leader Sagan.Nairo Quintana, the two-time runner-up from Colombia, also hasnt lost any time in the overall battle and is positioned seventh with the same time as Frme.The other overall favorites who have not lost time are Spanish Vuelta champion Fabio Aru of Italy, Romain Bardet of France and van Garderen.After a flatter Stage 3, more trouble lms in a hilly Stage 4, followed by the first mountain test on Stage 5.The 21-stage race ends July 24 in Paris. ' ' '